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In early spring, everything comes awake in the garden.
We’ll explain the best times to spray weeds in spring and when to wait for a better day.
Why Spray Weeds In Spring?

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Weeds that are more established in summer are much tougher to tackle.
You may spray them only to find the plant re-sprouting from the base.
In many cases, a combination of cutting, pulling, and spraying becomes necessary with well-established weeds.
Tackle problematic weeds in spring before they get the chance to go to seed and take over your garden.
These weed killers are usually applied in early spring in the South.
Treat your lawn once soil temperatures reach 50 degrees Fahrenheit when many weed seeds sprout.
Timing is critical here, as pre-emergent herbicides won’t work on weeds that have already sprouted.
Crabgrass will germinate once the soil surface reaches 55 degrees for four or five days.
The best time to spray is in the morning or late afternoon when the weather is calm.
Natural weed killers use vinegar, iron, or essential oils to kill weeds.
The same rules apply when spraying natural weed killers: Wait for a warm, sunny, calm day.
Alternatives To Spraying Weeds
Of course, good old-fashioned hand pulling is preferable where possible.
Focus on weeds that have started flowering since you want to interrupt their reproductive life cycle.
A quicker approach is to cover weedy areas with cardboard and then add a layer of mulch on top.
Finally,adding more desirable plantscan help with weed control.
Biology and Management of Crabgrass.
UMass Extension Turf Program.
Can I Treat Weeds With Roundup Weed & Grass Killer Products When It’s About to Rain?Roundup.