At the intersection of Highway 61 and 49, youll find a guitar monument that commemorates the historic story.

Visit The Delta Blues Museum

Get a crash course in blues history at the Delta Blue Museum.

The shop is a major gathering space during frequent festival weekends and also hosts regular live music.

The Shack Up Inn

The Shack Up Inn in Clarksdale, Mississippi provides a unique vacation experience for history buffs and music lovers of the blues.Credit: Tim Graham/Getty Images

The outfitter offers guided paddling tours of both the Lower Mississippi River and the Sunflower Rivers.

Multi-day trips are also available for those seeking a bigger adventure.

Take a self-guided tour to check out 15 differentMississippi Blues Trail markersspread across town.

Clarksdale Crossroads

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One nice evenings, take your meal to their expansive courtyard populated by picnic tables and string lights.

hookergrocer.com; 316 John Lee Hooker Ln.

Head to his legendary restaurant to try the delicacy, plus catfish, barbecue, and soul food.

Delta Blues Museum

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Specialty coffee drinks round out the offerings.

Guests enjoy the best of both an Airbnb or home-style stay and a traditional hotel reservation.

The lofts are each equipped with washers and dryers, plus full-sized kitchens and both full and half bathrooms.

Cat Head

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The onsite Juke Joint Chapel hosts regular live music, so you need not travel far for entertainment.

Quapaw Canoe Company

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Clarksdale, MS

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Ground Zero Blues Club

Credit:Courtesy of Visit Mississippi

Travelers Hotel

Credit:Courtesy of Visit Mississippi

5. Shack Up Inn

Credit: Robbie Caponetto