Plan an escape with your best friends to one of these delightful destinations.

Key Takeaways

Need a break from reality with the people who love you the most?

The South is home to tons of amazing vacation spots that are perfect for a girls’weekend getaway.

Fairhope, Alabama

Credit: Photo: Benjamin Callahan

No matter what youre up for, weve pulled together 29 fabulous experiences youll remember for a lifetime.

In downtown Fredericksburg,The Trueheart Hotelhas two suites in the main house along with 12 cottages.

For something more remote, check into the 112-acreTres Lunas Resorton Meusebach Mountain.

Colorful spring wildflowers in front of a Texas vineyard

Colorful spring wildflowers in front of a Texas vineyard.Credit:Getty Images

Start your winery tour withThe Reserve Wine Library at Becker Vineyardsfor tastings of exclusive vintages.

Taste award-winning wines and tour the geothermal barrel cellar atPedernales Cellars.

Winery events are free, but most charge for tastings.

Veritas Vineyard

Veritas Vineyard.Credit:Monticello Wine Trail

(Note: Reservations are recommended and often required for groups.)

Today, there are more than 300 wineries in Virginia, about 40 within 25 miles of Charlottesville.

Suppose you dont have a designated driver.

Viking Cooking School in Greenwood, MS

Credit: Photo: Jay Adkins

Cook in The Delta: Greenwood, MS

InGreenwood, stay atThe Alluvian.

Check out specialty shops likeRussell’s Warehouse Antiques & JewelryandThe Mississippi Gift Company.

Check out the Blues scene atGround Zero Blues CluborThe Crossroadsand visit theDelta Blues Museum.

Chicken and waffles at the Breakfast Klub

Credit:The Breakfast Klub

Don’t missMarch,Squable,Tris, andLucille’s, for starters.

For breakfast, try The Breakfast Klubs crispy salty-sweet chicken and waffles.

Just ensure to book early so you dont miss out on a place you have your heart set on.

Ryman Auditorium In Nashville, Tennessee

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Other famous Blues destinations in Mississippi include theB.B.

King Museum and Delta Interpretive Centerin Indianola and theGateway to the Blues Museumin Tunica.

Stay at theGraduate Nashvillewhere you’ll find fantastic photo ops throughout the design-focused space.

Crystal Bridges Museum of American Art (Bentonville, Arkansas)

Credit: Art Meripol

There’s a rooftop pool, a funky bar, and lots of graphic design elements to inspire you.

Then head out to a honky-tonk or concert venue like theRyman Auditoriumor theBluebird Cafeto hear some live music.

Nashvilles officialMusic City tourism sitelets you search by neighborhood and genre for live events.

Rip Van Winkle Gardens Jefferson Island

The Rip Van Winkle Gardens on Jefferson Island.Credit: Courtesy of Rip Van Winkle Gardens

The exhibitions rotate regularly, so no matter when (or how often!)

you go there should be something new to enjoy.

Waltz Across Cajun Country: Acadiana, LA

Southwest Louisiana is a hotbed of Cajun culture.

Austin City Limits Music Festival

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In the Hub City of Lafayette, downtown offers food and music around Jefferson Street.

Favorite music venues includeThe Continental Club,Antones Nightclub(known for the blues), andMohawk Austin.

Pair this with stays at unique hotels likeHotel Saint Cecilia,Arrive, or theHotel Van Zandt.

Highlands, North Carolina

Credit: Facebook/Old Edwards Inn and Spa

The Falls Cottages are clustered around a heated mineral pool, whirlpool, and outdoor fireplace.

Downtown Highlands has preserved its small-town character with mostly local shops and galleries.

The lake setting is ideal for outdoor activities, while theLakeHouse Spadelivers 25,000 square feet of pampering.

Kiawah Island, the Setting of the 2013 HGTV Dream Home

Credit:Image (c) Daniela Duncan / Getty Images

Many of the spa treatments relate to the Hill Country setting.

The four-star Inn on Biltmore Estate is one of three hotels on the sprawling property.

Head to nearbyEldr, which uses locally sourced ingredients, for dinner and cocktails.

Women riding Hobie Pedal Boards at Lake Austin Spa in Texas.

Lake Austin Spa is the first resort to have Hobie Pedal Boards.Credit: Lake Austin Spa

At theKentucky Horse Parkin Lexington, you’re able to tour the facilities by trolley.

Book a group lesson and guided trail ride atWhispering Woods Riding Stables, which has 250 acres to explore.

More than 150 miles of hiking trails are readily accessible from the (also walkable) downtown.

“Biltmore Estate” by MICHAEL BROWN is licensed under CC BY 2.0

“Biltmore Estate”.Credit: MICHAEL BROWN is licensed under CC BY 2.0

Stay close to theTennessee Aquariumand you’ll be within walking distance of the best riverfront attractions.

Alternatively, consider a tubing or white-rafting adventure with a local outfitter likeRiver Riders.

There are also several lodging options.

Gainesway Farm in Lexington, KY

Credit: Photo: Doug Prather

TheTimberTrek Adventure Parkfeatures the kind of challenging obstacles, bridges, and zip lines that encourage group camaraderie.

you’re free to buy a preset package or choose from the resort’s a la carte menu.

Along with wine, the crew serves hors d’oeuvres and a selection of domestic and imported beers.

Chattanooga, Tennessee

Credit:Rachelle Yingling / EyeEm/Getty Images

TheTrilogy Hotelis close to many of these historic sites.

Stroll through a cluster of specialty shops, includingPage & Paletteindependent bookstore.

Make your base camp at the venerableGrand Hotel Marriott Resort, Golf Club & Spain Point Clear.

Sunset at Harpers Ferry view from Maryland Heights

Credit:Ali Majdfar/Getty Images

TheHearse Ghost Tourscan carry up to nine guests inyou guessed ita hearse modified for sightseeing.

you could also board the Trolley of the Doomed with theGhosts & Gravestones Savannah Frightseeing Tour.

Keep the fun going with a stay in an 1873 mansion at theHamilton-Turner Inndowntown.

Adventures on the Gorge, New River Gorge, WV

Credit: Photo: Scott Suchman

TheConvention and Visitors Bureauoffers options ranging from historic churches to distilleries and breweries.

Then catch a ferry toFort Sumter, the site of the Civil Wars onset.

Treat yourself to afternoon tea inCamellias' stunning pink dining room.

Houseboat in Hot Springs Arkansas

Credit: Photo: Larry Elmore

Dine atFIG, where James Beard Award-winning Chef Mike Lata creates seasonal dishes that pay homage to the Lowcountry.

Stay at theQuirk Hotelfor easy access to city sights.

In theDeco District, you’ll see mind-boggling architecture from the 1920s, along with eateries and shopping.

The Ritz-Carlton Reynolds, Lake Oconee

Credit: Courtesy of the The Ritz-Carlton Reynolds, Lake Oconee

Prime sipping spots includeValkyrieorHodges Bend.

Stay at theAmbassador Hotel Tulsa, the historicMayo Hotel, or the modernAloft Tulsa.

This college town is home to the Georgia Bulldogs as well as storied music venues likeGeorgia Theaterand40 Watt.

Sail Key West

Credit:YuriF/Getty Images

Settle in atCreature Comforts Brewing Co.for a drink and a chat before seeing some live music.

Check out theWestside Provisions District, Atlantic Station, andPonce City Market.

And then there’s always Buckheads high-end shops.

Dexter Avenue King Memorial Baptist Church in Montgomery Alabama

Credit: C5Media / Getty Images

For accommodations, try theHotel Indigonear the Peachtree Center orThe Whitley, near Buckhead.

Pilot your own electriceBoat, or take a stand-up paddleboarding lesson withUrban Kaioutfitters.

Start with a stroll down Main Street, where youll find boutique shops, art galleries, and cafes.

Beautiful statue in Bonaventure Cemetery in Savannah

Credit: Getty Images/Walter Bibikow

Dont missFalls Park on the Reedy, a picturesque oasis featuring the stunning Liberty Bridge and cascading waterfalls.

Creative types in your group will enjoy a visit to theGreenville County Museum of Artand downtown galleries too.

Catch a performance at thePeace Center,a cultural hub hosting Broadway shows and concerts.

Charleston SC Rainbow Row

Credit: Pgiam / Getty Images

University of Richmond

Credit: Courtesy University of Richmond

Downtown Tulsa, Oklahoma

Credit: traveler1116/Getty Images

Athens, Georgia- The Classic City

Credit: John Greim/Getty Images

Atlanta, Georgia skyline from Atlantic station at dusk with autumn foliage.

Tampa Riverwalk

Credit:csfotoimages/Getty Images

Falls Park on the Reedy

Credit:Nikola Spasic Photography/Getty Images